An Conair Ionsúite in Vivo As Foirmlithe Soladach

Is é an cosán ionsúite coitianta d’ullmhóidí soladacha ná go gcaithfidh ullmhóidí soladacha dul trí phróiseas díscaoilte den druga tar éis riarachán béil sular féidir iad a ionsú isteach sa tsruth fola tríd an membrane cille epithelial intestinal gastrach agus a n-éifeachtaí teiripeacha a fheidhmiú. Go háirithe i gcás roinnt drugaí dothuaslagtha, beidh próiseas díscaoilte na ndrugaí ina phróiseas teorannaithe ráta ionsú drugaí. Má tá an ráta díscaoilte beag agus go bhfuil an ionsú mall, beidh an tiúchan drugaí fola deacair an tiúchan teiripeach éifeachtach a bhaint amach. Déan comparáid idir conairí ionsúcháin foirmlithe éagsúla tar éis riarachán béil anseo
Foirm dosage
Ionsú le linn próisis díscaoilte nó scaipthe
Táibléad
○○○
Capsúil
Gráinníní
Púdar
×○○
Gníomhaire fionraí
Gníomhaire réitigh
Nóta: ○ - Tá an próiseas seo ag teastáil; X -- Níl gá leis an bpróiseas seo
After oral administration, tablets and capsules first disintegrate into fine particles, and then drug molecules dissolve from the particles. The drugs are absorbed into the bloodstream through the gastrointestinal mucosa. There is no disintegration process after oral administration of granules or powders, and they quickly disperse with a larger specific surface area, resulting in faster dissolution, absorption, and efficacy of the drug. The particles of the suspension are smaller, so the dissolution and absorption process of the drug is faster. However, after oral administration of the solution, there is no disintegration or dissolution process, and the drug can be directly absorbed into the bloodstream, resulting in a shorter onset time of the drug. The general order of absorption of oral preparations is: solution>suspension>powder>granule>capsule>tablet>pillín.
Tá scaipeadh ullmhóidí soladacha i gcáithníní fíneáil sa chorp ar cheann de na bearta éifeachtacha chun an ráta díscaoilte a fheabhsú agus an ráta ionsú a luathú.